WE ARE SEISMIC

The Machine Learning Immunology Company

Our integrated platform, called IMPACT™, embeds machine learning and structural biology at the center of the biologics design and test process. We are shifting the paradigm for discovery and development of biologics in immunology by integrating:

  • Machine Learning
  • Protein Engineering
  • Structural Biology
  • Accelerated Drug Design
  • Translational Immunology

MORE TO COME

New information about Seismic Therapeutic will be coming soon, as we reveal more about our exciting approach to drug discovery..

CAREERS

Please find currently available job posts below. To apply, please send an email with a CV to careers@seismictx.com.

.

 

General Role

 

In coordination with scientific leadership, you would play a central role in designing and implementing Seismic’s pipeline, with particular focus on infrastructure, architecture, software and data engineering. As an Engineer, you will be a part of a fast-paced AI/ML team dedicated to advancing discovery and pre-clinical programs. Successfully meeting these challenges will require not only a broad range of computational and engineering acumen, independent thinking, and an aptitude for troubleshooting, but also a strong, creative drive to develop new methods as the need arises.

 

Your work in this role would be in collaboration with scientists and computational experts throughout Seismic, learning and contributing to our pipeline, including the discovery of both tools and lead candidate biotherapeutics. You would be responsible for understanding project goals and for creatively optimizing solutions to ensure their success. Over time you would take on additional responsibilities and contribute to new projects.

 

 

Responsibilities

 

  • Develop and manage the computational backbone for next-generation machine learning-based design of protein therapeutics
  • Orchestrate the integration of information systems, lab robotics and machine learning platforms for efficient data flow
  • Work at the interface of computation and experiments to provide user-friendly, powerful tools for visualization and data processing
  • Work in close collaboration with experimental and computational teams to evolve the overall technology platform
  • Share recommendations and insight for pipeline improvement toward higher-throughput and efficiency

 

 

Basic Qualifications

 

  • PhD (or BSc/MSc with 2+ years of practical experience) in computer science, data science, bioinformatics, or a related field
  • Hands-on and solution-oriented attitude; ability to come up with pragmatic, robust and flexible implementations in a rapidly evolving environment
  • Strong software engineering and development skills (Python, API development, SQL/NoSQL data models, testing, deployment)
  • Cloud computing experience (preferably AWS)
  • Strong analytical thinker who can clearly communicate with computational and experimental biologists, team-oriented
  • Strong collaborative, organizational, and presentation skills

 

 

Preferred Qualifications

 

  • Computational biology/bioinformatics
  • Front-end development (JavaScript/TypeScript, React, or similar)
  • Workflow systems (e.g. Apache Airflow)
  • Lab information and/or robotics systems (e.g. Hamilton, Tecan)
  • Mentoring and managing experience

 

We are an Equal Opportunity employer committed to a diverse workforce. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability.

Applicants please send an email to careers@seismictx.com, including a resume and a short self-introduction.

 

 

 

General Role

 

In coordination with scientific leadership, you would play a central role in designing and implementing Seismic’s pipeline, with particular focus on immunology. As a Senior Scientist/ Scientist, you will be a part of a fast-paced immunology team dedicated to advancing discovery and pre-clinical programs. Successfully meeting these challenges will require not only a broad range of immunology skills, independent thinking, and an aptitude for troubleshooting, but also a strong, creative drive to develop new assays as the need arises.

 

Your work in this role would be in collaboration with scientists and computational experts throughout Seismic, learning and contributing to our pipeline, including both in vivo and in vitro preclinical studies. You would be responsible for understanding project goals and for creatively optimizing solutions to ensure their success. Over time you would take on additional responsibilities and contribute to new projects.

 

 

Responsibilities

 

  • Co-lead internal drug discovery program(s), assume responsibility for in vivo and in vitro preclinical studies to deeply characterize drug candidates
  • Independently design, develop, analyze, and troubleshoot experiments
  • Mentor others in the design, execution and analysis of experiments that support programs
  • Make independent, intellectual, and technical contributions to projects, while working collaboratively within the Seismic team
  • Communicate results to both internal and external stakeholders
  • Strong interpersonal skills to foster an open and collaborative environment

 

 

Basic Qualifications

 

  • Co-lead internal drug discovery program(s), assume responsibility for in vivo and in vitro preclinical studies to deeply characterize drug candidates
  • Independently design, develop, analyze, and troubleshoot experiments
  • Mentor others in the design, execution and analysis of experiments that support programs
  • Make independent, intellectual, and technical contributions to projects, while working collaboratively within the Seismic team
  • Communicate results to both internal and external stakeholders
  • Strong interpersonal skills to foster an open and collaborative environment

 

We are an Equal Opportunity employer committed to a diverse workforce. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability.

 

Applicants please send an email to careers@seismictx.com, including a resume and a short self-introduction.

 

 

 

 

 

General Role

 

In coordination with scientific leadership, you would play a central role in designing and implementing Seismic’s pipeline, with particular focus on immunology. As a Senior Associate Scientist I/II, you will be a part of a fast-paced immunology team dedicated to advancing discovery and pre-clinical programs. Successfully meeting these challenges will require not only a broad range of immunology skills, independent thinking, and an aptitude for troubleshooting, but also a strong, creative drive to develop new assays as the need arises.

 

Your work in this role would be in collaboration with scientists and computational experts throughout Seismic, learning and contributing to our pipeline, including both in vivo and in vitro preclinical studies. You would be responsible for understanding project goals and for creatively optimizing solutions to ensure their success. Over time you would take on additional responsibilities and contribute to new projects.

 

 

Responsibilities

 

  • Design and perform studies, including PK/PD and efficacy, in animal models
  • Develop ex vivo assays/analysis to characterize drugs’ mechanism(s) of action
  • Plan, perform, analyze, interpret and report results from the studies with minimal supervision
  • Interface with CROs and vendors
  • Mentor others in the design, execution and analysis of experiments that support programs
  • Document data in electronic laboratory notebook and write technical reports
  • Communicate directly results to internal stakeholders and at program team meetings
  • Strong interpersonal skills to foster an open and collaborative environment

 

 

Basic Qualifications

 

  • BS degree plus 5-10+ years of experience in a lab setting or MS plus 2-8+ years of experience in a lab setting
  • Hands-on experience with animal models for autoimmune diseases is preferred
  • Experience with testing of therapeutics in animal models is an advantage
  • Hands-on experience with ELISA, western blot, Luminex/MSD, flow cytometry is preferred but not required
  • Capability to anticipate and recognize potential issues within experimental designs and effectively communicate alternatives
  • Ability to work collaboratively, provide scientific insight, and communicate clearly in writing and orally
  • Excellent record keeping abilities to document analytical data generated in support of regulatory requirements
  • Ability to manage multiple projects, prioritize work and meet tight deadlines
  • Curious in exploring new options for model development, bold in proposing creative experimental designs and ideas, relentless in pursuing successful outcomes

 

We are an Equal Opportunity employer committed to a diverse workforce. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability.

 

Applicants please send an email to careers@seismictx.com, including a resume and a short self-introduction.

 

 

 

 

 

General Role

 

In coordination with scientific leadership, you would play a central role in designing and implementing Seismic’s pipeline, with particular focus on immunology. As a Senior Associate Scientist I/II, you will be a part of a fast-paced immunology team dedicated to advancing discovery and pre-clinical programs. Successfully meeting these challenges will require not only a broad range of immunology skills, independent thinking, and an aptitude for troubleshooting, but also a strong, creative drive to develop new assays as the need arises.

 

Your work in this role would be in collaboration with scientists and computational experts throughout Seismic, learning and contributing to our pipeline, including both in vivo and in vitro preclinical studies. You would be responsible for understanding project goals and for creatively optimizing solutions to ensure their success. Over time you would take on additional responsibilities and contribute to new projects.

 

 

Responsibilities

 

  • Develop functional cell-based in vitro assays with primary cells from humans and preclinical animal species to characterize drugs’ mechanism(s) of action
  • Plan, perform, analyze, interpret and report results from the studies with minimal supervision
  • Eager to learn handling of preclinical animal models to provide help to our in vivo team when needed
  • Interface with vendors for acquisition of relevant materials and reagents
  • Mentor others in the design, execution and analysis of experiments that support programs
  • Document data in electronic laboratory notebook and write technical reports
  • Communicate directly results to internal stakeholders and at program team meetings
  • Strong interpersonal skills to foster an open and collaborative environment

 

 

Basic Qualifications

 

  • BS degree plus 5-10+ years of experience in a lab setting or MS plus 2-8+ years of experience in a lab setting
  • Hands-on experience with ELISA, western blot, Luminex/MSD, flow cytometry
  • Experience with testing of biologics in in vitro settings is an advantage
  • Hands-on experience with tissue culture, archiving, transfection and cell-based functional assays, primary hematopoietic cell isolation and culture
  • Capability to anticipate and recognize potential issues within experimental designs and effectively communicate alternatives
  • Ability to work collaboratively, provide scientific insight, and communicate clearly in writing and orally
  • Excellent record keeping abilities to document analytical data generated in support of regulatory requirements
  • Ability to manage multiple projects, prioritize work and meet tight deadlines
  • Curious in exploring new options for model development, bold in proposing creative experimental designs and ideas, relentless in pursuing successful outcomes

 

We are an Equal Opportunity employer committed to a diverse workforce. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability.

 

Applicants please send an email to careers@seismictx.com, including a resume and a short self-introduction.

 

 

 

 

 

 

Who we are

Seismic Therapeutic is a VC-backed biotechnology startup focused on the intersection of structure, protein engineering, machine learning and immunology founded by Tim Springer, Jeff Ravetch, Debora Marks and Alan Crane.

 

What we offer you

As a member of our new and quickly growing company, you’ll help us shape Seismic from the very beginning into a startup that not only takes its scientific mission seriously but also provides a positive and supportive workplace environment and culture. Seismic will have the opportunity to benefit from the insight, diversity, and talent that you’ll bring. Together, we’ll help bring therapeutics to the patients who need them most.

 

Our mission

Seismic is determined to help patients in need, starting with novel approaches to protein engineering, machine learning and immunology, and ending with clinic-ready drugs. At our core, our focus is on phenomenal science, meritocracy, a superstar team, supportive culture, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality – all we need is you! Success will enable treatment for millions of patients with currently incurable, often disabling and deadly diseases, and we invite you to become a part of that.

 

Where?

Seismic is located in the dynamic biotech community in Watertown, alongside other new companies that are turning ideas into reality and changing the biotech and medical scenes for the better. We are thrilled to expand our Team with hardworking, highly qualified, highly motivated individuals to join us in our lab space.

CONTACT US

Seismic Therapeutic is growing and connecting within the biotech community, and we invite you to reach out to us at