At Seismic, our open and hyper-collaborative process is what yields results. We gain focus alongside curiosity. We are dedicated to our rigorous science and determined to have impact for patients. Doing it all, together, is what keeps us going. Let’s fuse our ideas and open the door to the uncharted.

to do more.
Being a Seismonaut means being relentlessly curious, open, transparent, and decisive. But above all, putting the team first. Here’s how we do it:
At Our Core
We have our eyes on the prize - combining a level of accountability with exceptional, exciting science, but we also have a serious respect for our goals and believe in our people.
In Our Approach
We are open to the possibilities of the new and the uncharted. We fully believe that our impact on the drug discovery paradigm directly correlates to our willingness to embrace curiosity.
In Our Process
We believe our hyper-collaborative style provides a fertile ground for discovery, having a positive impact both inside and outside of Seismic.

While we are focused on this new era of drug discovery, our main focus is our why: creating IMPACT for patients.

We need you on our team.

Get Inspired at Seismic.

Senior Director, Head of CMC

About Seismic Therapeutic

Seismic, a biotechnology company, is determined to help patients by integrating machine learning, structural biology, protein engineering, and translational immunology to create optimized therapies for patients with autoimmune disease.

At our core, we are focused on phenomenal science, supportive culture, a diverse team, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that.

The opportunity

Seismic is seeking an experienced CMC professional to lead and run Seismic’s CMC activities.

As Senior Director you will help to establish or refine key systems and best practices and be the overall responsible day-to-day leader from a strategic, technical, and operational standpoint.

In addition to being a key contributor to the CMC strategy, this is a role that requires a dynamic, hands-on leader, who will move proactively lead the CMC function and interface seamlessly throughout our R&D org.

This is an exciting opportunity to join as a key member of the Seismic team.

The Role
Senior Director, Head of CMC

Seismic Therapeutic is seeking a highly experienced and motivated Senior Director, Head of CMC to lead our CMC operations within our Drug Creation organization. This is a critical role, that will report to Seismic’s CTO, that will oversee all aspects of our CMC activities, from cell line development to drug product manufacturing for our biologic modalities.


  • Oversee day-to-day CMC operations, which are completely externalized.
  • Own and continuously update our CMC strategy as each new development program comes online.
  • Leverage support from external consultant SMEs as needed.
  • Manage all of the CDMOs and CROs in our supply chain covering cell line development, process and formulation development, analytics, GMP drug substance and drug product manufacturing, label, pack, distribution, and storage of our cell lines and products.
  • Manage CMC within budget and keep timelines on track.
  • Anticipate and troubleshoot roadblocks and hurdles – communicating with appropriate internal stakeholders as needed


  • Ph.D. in Chemistry, Biochemistry, or a related field.
  • 18+ years of experience in CMC operations, preferably in large pharma and small biotech with a specific focus on biologic modalities, such as Fc fusions and monoclonal antibodies.
  • A technical background in process development is desirable with broad knowledge around upstream, downstream, formulation and analytical development
  • Proven track record of success in managing external CMC operations for biologic drug products.
  • Strong understanding of regulatory requirements for biologic products.
  • Excellent communication, collaboration, and problem-solving skills.

This position will be in our Watertown, MA office location.


Equal Opportunity Employer

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

A Space for Seismic Discovery

Shifting the horizon requires creating the right environment for our Seismonauts to thrive. Our space fosters the inclusivity and integration we run on – with open collaborative work areas that allow cross- pollination of interests and departments. However, setting the stage for success goes beyond our galaxy walls. Seismic offers a competitive benefits package that is structured to create balance and maintain the expertise and talent we need on our mission.

Be an IMPACTor

Our team of Seismonauts is passionate about shifting things for the better, not only in developing breakthrough medicines, but also in making a difference to the causes and communities that matter to us.

Our IMPACTor Leaders show us the way. As an employee-led collaborative, IMPACTors initiate social events, elevate diversity awareness, and host philanthropic and volunteer activities. These initiatives are proudly started within Seismic, but have profound impact in the community.


This links to an external website.