Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub.

We are seeking an experienced and motivated Director/Senior Director of Program Management to drive our cross-functional program teams and collaborate with the senior R&D leadership to develop and execute strategy and operations as we head into the clinic for our two lead development programs: a pan‑immunoglobulin (Ig) G protease sculpting (Sc) enzyme program (S-1117) and a PD-1 agonist:Fc gamma receptor IIb selective Dual-cell Bidirectional (DcB) antibody program (S-4321).

Who You Are:

• A dynamic program director with deep experience in clinical development stage programs with a strong preference for experience with biologics development, immunology therapeutic areas and/or rare disease
• Passionate about improving the lives of people living with immunological diseases
• Strong interpersonal skills to influence and motivate others, reach organizational alignment and manage conflict, including collaborating with scientists and functional experts across multiple levels and working styles
• Effectively able to communicate complex scientific and strategic topics to variety of audiences
• Exceptional organizational skills, with ability to manage multiple cross-functional projects
• Proactive and “roll-up your sleeves” to dive in with minimal supervision and thrive in a fast-paced, fluid environment
• Excited to help define and embed program management best practices throughout the pipeline and be a coach and resource for colleagues across the organization

What You’ll Do:

• Achieve key program and critical corporate objectives by partnering with senior R&D leadership to drive cross-functional program teams (Clinical, Preclinical Translation, Manufacturing, Commercial, etc.)
• Facilitate program team discussions (including documenting agendas, minutes, decision logs, etc.) for cross-functional awareness and decision-making including scenario planning, decision criteria, articulating tradeoffs, and implications on timelines, resources and objectives
• Develop and be accountable to track integrated timelines, manage milestones and ensure timely communication on key activities
• Collaborate with functional experts to address issues and challenges, including proactively identifying and creating mitigation/contingency plans for program risks
• Support development of integrated strategy including articulating long-term product strategies, functional plans and interdependencies
• Enable effective and consistent performance within program teams including supporting and coaching team members to optimize collaboration and delivery
• Contributing your expertise to build clinical development capabilities and support business operations as needed across the organization
• Partner with program management colleagues to ensure consistency, and coordination across portfolio, and establish/evolve best practices and help embed project management into our teams as our pipeline grows and matures

Qualifications:

• BS in scientific or business-related field required; advanced degree preferred
• 8-10 years of experience in a biotechnology or pharmaceutical setting and at least 5-7 years in program/portfolio and/or clinical operations management with a demonstrated competency with programs in clinical stage, in particular for biologics in immunologic diseases and/or rare disease
• Strong analytical and technical skills, including proficiency in project management practices, project planning, and decision-making
• Clear communication skills with ability to articulate complex strategic considerations and influence discussions to address challenges and reach decisions
• Command of MS office suite and project management tools (MS Project/Timeline, ThinkCell, SmartSheet)
• Experience in both large and small company environments a plus

At our core, we are focused on phenomenal science, supportive culture, a superstar team, meritocracy, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion and talent – we’ll bring novel therapeutics to the patients who need them the most.

APPLY HERE

Seismic Therapeutics is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

About Seismic: Seismic is determined to help patients with unmet need by integrating machine learning, structural biology, protein engineering, and translational immunology to generate clinic ready drugs. At our core, we are focused on phenomenal science, supportive culture, a superstar team, meritocracy, and patient-centric goals. Seismic has the tools, skills, ideas, and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that.

Responsibilities: 

• Perform protein expression, purification and quality control of fusion proteins and antibodies.
• Assist in establishing and carrying out a wide variety of essays to assess biochemical/biophysical properties    and develop characteristics of experimental therapeutic molecules.
• Conduct protein engineering processes to improve the characteristics of experimental therapeutic molecules.
• Assist in the discovery and optimization of antibodies and antibody components.
• Conduct routine molecular biology work like closing, PCR, DNA prep, agarose gel electrophoresis.
• Assist in developing molecules for clinical stage projects and adheres to company timelines.
• Carefully document research and effectively communicate results to relevant members of the team.

Who You Are: 

• A rigorous scientist with molecular biology and microbial work experience.
• Organized, with good time management and planning skills.
• A collaborative teammate who thrives in a scientifically diverse, fast-paced, team oriented, start-up environment
• Passionate about improving patients’ lives.

Education/Experience Required: Master’s degree in Biology, Biochemistry, Biotechnology or related field plus 12 months of experience as a Research Scientist with protein biochemistry hands-on industry experience.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion and talent – we’ll bring novel therapeutics to the patients who need them the most.

TO APPLY

Please send resume to careers@seismictx.com

Seismic Therapeutics is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.