At Seismic, our open and hyper-collaborative process is what yields results. We gain focus alongside curiosity. We are dedicated to our rigorous science and determined to have impact for patients. Doing it all, together, is what keeps us going. Let’s fuse our ideas and open the door to the uncharted.

While we are focused on this new era of drug discovery, our main focus is our why: creating IMPACT for patients.

We need you on our team.

Get Inspired at Seismic.

Director, Clinical Operations 

About Seismic: Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing clinical and preclinical best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub.

About the Role: We are seeking an experienced and motivated Director of Clinical Operations who will play a critical role in the planning, execution and management of Seismic’s clinical studies. You will oversee the day-to-day clinical trial operations and contribute to planning of the overall clinical development strategy for our clinical and IND-enabling stage programs.

Who You Are:

  • An experienced clinical operations and clinical trial management professional ideally having experience with biologics development, immunology therapeutic areas and/or rare disease
  • Passionate about improving the lives of people living with immunological diseases
  • Strong interpersonal skills to influence and motivate others, reach organizational alignment and manage conflict, including collaborating with scientists and functional experts across multiple levels and working styles
  • Exceptional organizational skills, with ability to manage multiple cross-functional projects
  • Proactive and “roll-up your sleeves” mindset to dive in with minimal supervision and thrive in a fast-paced, fluid environment
  • Excited to help define and build the clinical operations function for a growing and exciting pipeline

What You’ll Do:

  • Achieve clinical milestones and critical corporate objectives by partnering with cross-functional Development team (including senior R&D leadership, Clinical, Preclinical Translation, CMC, etc.)
  • Work collaboratively with and manage CRO partners including responsibilities for day-to-day coordination of activities, creation and oversight of clinical study documents, deliverables, risk mitigation
  • Establish relationships with clinical trial sites to help ensure high quality data collection, timely study recruitment and enrollment, and compliance with regulatory standards
  • Ensuring adherence to global regulatory requirements and Good Clinical Practices
  • Develop and manage study budgets including tracking and reconciliation, balancing achievement of milestones with financial stewardship
  • Brainstorm and articulate clinical timeline and operations scenario plans and work collaboratively with cross-functional team to understand implications of decisions
  • Collaborate with functional experts to address issues and challenges, including proactively identifying and creating mitigation/contingency plans for program risks
  • Support development of integrated strategy including articulating long-term product strategies, functional plans and interdependencies
  • Provide input into developing quality systems including SOPs and other resources
  • Contributing your expertise to build clinical development capabilities and support business operations as needed across the organization

Qualifications:

  • BS in scientific field required; advanced degree preferred
  • ~10 years of experience in a biotechnology or pharmaceutical setting and at least 5-7 years in clinical operations/clinical trial management with demonstrated results in a fast-paced environment, ideally in both large and small, companies
  • Experience with CRO/vendor selection and management
  • Strong command of GMP requirements and ICH/GCP guidelines and global clinical trial regulations
  • Strong analytical and technical skills, including proficiency in project management practices, project planning, and decision-making
  • Clear communication skills with ability to articulate complex strategic considerations and influence discussions to address challenges and reach decisions
  • Experience with biologics in immunologic diseases and/or rare disease is preferred

At our core, we are focused on phenomenal science, supportive culture, a superstar team, meritocracy, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion and talent – we’ll bring novel therapeutics to the patients who need them the most.

APPLY HERE

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

Scientist / Senior Scientist, Machine Learning

About Seismic

Seismic Therapeutic, a cutting-edge biomedicines company at the intersection of machine learning, protein engineering, and immunology, is seeking a creative, independently-minded machine learning scientist to help accelerate the Impact Platform for the computational discovery and optimization of new biologic drugs. Seismic’s machine learning platform enables on-demand generation and optimization of protein therapeutics to fight diseases of the immune system, using the power of artificial intelligence to translate audacious ideas into breakthrough drugs. We are dedicated to building a supportive culture around a superstar team, while keeping the unmet needs of patients at the center of our goals. Seismic has the tools, skills, ideas and people to make this vision a reality.

Working closely with our team of machine learning scientists, structural biologists, immunologists and others, you will develop and apply innovative machine learning approaches to optimize natural proteins for clinical applications and design novel classes of synthetic proteins with therapeutic functions.

Who you are and what you bring:

  • A rigorous machine learning scientist with a deep understanding of molecular biology, protein biochemistry and structure.
  • Appreciation of the characteristics that make a robust biologic drug.
  • Hands-on experience with protein design models incorporating sequence (evolutionary sequence models and large language models) and/or structure (diffusion and inverse folding models).
  • Ability to communicate complex machine learning and computational concepts to audiences with a wide range of backgrounds and technical familiarity.
  • Experience working with wet lab teams to bridge the divide from in-silico designs to real-world applications.
  • Driven and conscientious, thriving in a fast-paced, entrepreneurial environment.
  • Passionate about improving patients’ lives.

Core Responsibilities:

  • Design and train new classes of machine learning models to optimize natural proteins for therapeutic properties and design synthetic proteins with novel therapeutic functions.
  • Spearhead computational de novo antibody design efforts to create new therapeutics targeting challenging antigens.
  • Integrate diverse external and internal data sources including protein sequence, structure, function, and molecular characterization data to enable detailed modulation and multi-objective optimization of protein properties.
  • Work with a diverse team of protein scientists, immunologists, and clinical experts to tailor modeling efforts toward high-impact therapeutic applications.
  • Establish robust data infrastructure to enable machine learning model training and deployment of data analysis and visualization tools.
  • Develop production-quality code in a team setting for use by both computational and wet-lab scientists.
  • Present progress from scientific work in regular meetings and prepare reports and slide decks for broader internal and external communication.

Required Qualifications:

  • PhD in Mathematics, Computational Biology, Computer Science, Statistics or a related field. Exceptional candidates with extensive computational experience and a PhD in a non-computational field will also be considered.
  • 3+ years of industry experience with developing and applying machine learning methods to create new biological drugs, using deep learning models such as variational autoencoders and graph neural networks.
  • Application of ML in the field of drug discovery is essential with hands-on experience in the following: protein engineering, or statistical genetics are especially relevant.
  • Demonstrated experience collaborating with wet lab scientists to generate and analyze real-world data in an applied setting, especially in the context of pharmaceutical development.
  • Proficiency in Python and data analysis with Numpy/Scipy, R, or another statistical programming language.
  • A strong drive to collaborate and communicate with a diverse and vibrant team of both dry and wet lab scientists.

It’s a plus but not required:

  • Experience with AWS, Google Cloud, or another cloud computing framework.
  • Familiarity with Dash, R Shiny, or another interactive app development framework.
  • Application of ML in the fields of genomics and immunology.
  • Publications in major scientific journals that apply machine learning methods to problems in molecular or structural biology.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion, and talent – we’ll bring novel therapeutics to the patients who need them the most.

APPLY HERE

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

Alert about deceptive recruitment activities:
Please be aware of the potential for scams from individuals, organizations and internet sites that claim to represent Seismic Therapeutic in recruitment activities. They may be trying to fraudulently collect sensitive personal information and, if so, please report any suspicious activity to local authorities for identity theft. Seismic conducts a formal recruitment process for all authorized positions. Unless you apply directly to a job listing, we will not contact you via text message, email or any other channels.

Inspired
to do more.
Being a Seismonaut means being relentlessly curious, open, transparent, and decisive. But above all, putting the team first. Here’s how we do it:
Intensive
At Our Core
We have our eyes on the prize - combining a level of accountability with exceptional, exciting science, but we also have a serious respect for our goals and believe in our people.
Inclusive
In Our Approach
We are open to the possibilities of the new and the uncharted. We fully believe that our impact on the drug discovery paradigm directly correlates to our willingness to embrace curiosity.
Integrative
In Our Process
We believe our hyper-collaborative style provides a fertile ground for discovery, having a positive impact both inside and outside of Seismic.

A Space for Seismic Discovery

Shifting the horizon requires creating the right environment for our Seismonauts to thrive. Our space fosters the inclusivity and integration we run on – with open collaborative work areas that allow cross- pollination of interests and departments. However, setting the stage for success goes beyond our galaxy walls. Seismic offers a competitive benefits package that is structured to create balance and maintain the expertise and talent we need on our mission.

Be an IMPACTor

Our team of Seismonauts is passionate about shifting things for the better, not only in developing breakthrough medicines, but also in making a difference to the causes and communities that matter to us.

Our IMPACTor Leaders show us the way. As an employee-led collaborative, IMPACTors initiate social events, elevate diversity awareness, and host philanthropic and volunteer activities. These initiatives are proudly started within Seismic, but have profound impact in the community.

© 2025 SEISMIC TX. ALL RIGHTS RESERVED.
 
 

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