Novel engineered Fc-fused pan-IgG protease demonstrates deep, rapid and sustained reduction of IgG levels and ability to address multiple pathogenic mechanisms as a single drug molecule
Preclinical data supports potential for S-1117’s multi-mechanistic action to address unmet need in myasthenia gravis
Company expects to initiate first-in-human Phase 1 clinical trial of S-1117 in 1H 2025
Watertown, Mass., October 15, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced the presentation of new preclinical data for its pan‑immunoglobulin G (IgG) sculpting enzyme candidate, S-1117, at the Myasthenia Gravis Foundation of America (MGFA) Scientific Session at the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM) 2024 annual meeting in Savannah, Georgia.
S-1117 is a novel engineered Fc-fused pan-IgG protease targeting IgG autoantibodies that play a key role in the pathogenesis of a range of chronic and acute autoantibody mediated diseases, including myasthenia gravis (MG), a chronic neuromuscular autoimmune disorder. Seismic plans to initiate a Phase 1 clinical trial of S-1117 in healthy volunteers in the first half of 2025.
“S-1117 has shown the unique ability to target multiple orthogonal pathogenic mechanisms within a single molecule, and we believe this multi-mechanistic approach has the potential to drive deeper responses and offer improved clinical outcomes for MG patients, as well as for patients with other autoantibody-mediated diseases,” said John Sundy, MD, PhD, Chief Medical Officer and Head of R&D at Seismic Therapeutic. “Despite recent treatment advancements, there remains a significant opportunity to address the large proportion of MG patients who do not achieve remission or low disease activity with currently approved therapies. We believe S‑1117 can offer advantages over existing treatment options and look forward to advancing S‑1117 into first-in-human Phase 1 clinical studies in the first half of next year.”
The S-1117 preclinical data presented at AANEM showed deep, rapid and sustained reduction of all IgG subclasses. S-1117 also demonstrated the ability to directly cleave circulating and immune complexed IgG, as well as the IgG B cell receptor expressed on memory B cells. Moreover, current S-1117 PK/PD modeling indicates the potential for a convenient small volume, subcutaneous, self-administered treatment regimen administered every 4-6 weeks.
Highlights of the Presentation
In vitro, S-1117 was shown to cleave soluble forms of IgG from healthy volunteers and MG patients. The results support additional key attributes of S-1117:
In vivo studies performed with S-1117 in rabbit and mouse models showed rapid, deep and sustained IgG reduction and demonstrated cleavage of the B cell receptor within hours after both intravenous and subcutaneous administration.
Projections of human PK and PD through quantitative systems pharmacology (QSP) modeling for S-1117 indicate that infrequent chronic low doses can achieve titratable IgG reductions of 90% or greater. PK/PD modeling further supports the potential for a subcutaneous, self-administered treatment regimen to achieve therapeutic levels of IgG reduction at doses as low as <1mg/kg of drug administered monthly. In addition, given the rapid onset of action, S-1117 is predicted to be applied to acute conditions, such as MG crisis.
The poster for the data presented at AANEM is available here on Seismic’s website.
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ
212-362-1200
emiley.demick@precisionaq.com
Watertown, Mass., September 30, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced the company’s participation in three upcoming scientific and medical conferences, presenting on Seismic’s emerging pipeline of novel therapeutics to treat rare and prevalent autoimmune diseases, as well as its proprietary IMPACT platform that applies machine learning to biologics drug discovery.
Details of Seismic’s presentations and poster sessions are as follows:
October 3-4: Biologics US, San Diego, CA
Presentation Title: Structure empowered IMPACT platform in the discovery & development of Immunoglobulin Sculpting (IgSc) enzyme & Dual-cell Bidirectional (DcB) antibody drugs for immunological diseases
Session: Track 1: Computational Tools, AI/ML-Guided Engineering
Date: Friday, October 4
Time: 2:15 p.m. PT
Presenter: Yi Xing, PhD, Senior Director, Head of Structural Biology
October 15-18: Myasthenia Gravis Foundation of America Scientific Session at American Association of Neuromuscular & Electrodiagnostic Medicine Annual Meeting, Savannah, GA
Presentation Title: Preclinical pharmacology of S-1117, a novel engineered Fc-fused IgG cleaving enzyme, for chronic treatment of autoantibody-mediated diseases including Myasthenia Gravis
Session: Therapeutics
Date: Tuesday, October 15
Time: 10:10 a.m. ET
Presenter: Julia Manasson, MD, Medical Director, Clinical & Translational Medicine
October 15-18: CHI Immunogenicity & Bioassay Summit, Washington, DC
Presentation Title: Machine learning for deimmunization and multi-objective optimization of biologics
Session: Immunogenicity Prediction & Control – Deimmunization, Developability, and Machine Learning
Date: Friday, October 18
Time: 3:35 p.m. ET
Presenter: Ryan Peckner, PhD, Director, Head of Machine Learning
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ
212-362-1200
emiley.demick@precisionaq.com
WATERTOWN, Mass., September 23, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that Julie Eastland has been appointed as Independent Director to Seismic’s Board. Ms. Eastland brings more than 30 years of experience in finance and strategy in clinical stage biotechnology companies delivering novel therapeutics to patients with unmet needs in oncology and immunology.
“It is with much excitement that we welcome Julie to our Board of Directors. As a proven independent Director and executive with decades of experience in the biopharmaceutical industry, Julie brings deep knowledge across the company growth and drug development continuum, from discovery through commercialization,” said Jo Viney, PhD, Co-founder, President and CEO of Seismic Therapeutic. “Julie’s wide range of leadership roles, experience with platform and asset-focused companies, and successful track record guiding biotechnology companies through significant organizational growth, and background spanning strategy, financial and operational perspectives will serve us well as we continue to mature our business and advance our first pipeline candidates into the clinic.”
“It is a privilege to join Seismic’s Board as the company continues to make a major shift in how immunology therapies are discovered and developed, enabled by machine learning,” said Julie Eastland. “I look forward to working with the accomplished team at Seismic as we build and advance a clinical pipeline of innovative enzyme and antibody drug programs to modulate the immune system in new and better ways. I believe Seismic’s approach has the potential to result in powerful, novel treatments for patients suffering from autoimmune diseases of high unmet need.”
Ms. Eastland most recently served as Chief Executive Officer and Board Director of Harpoon Therapeutics, formerly a publicly traded company (Nasdaq: HARP) focused on T-cell engager cancer immunotherapies, from November 2021 through its acquisition by Merck & Co in March of 2024. Prior to November 2021, she was a Harpoon Board Director and Chair of the Audit Committee from October 2018. Ms. Eastland has served in a variety of C-level executive roles for both private and public companies, including Chief Operating Officer/Chief Financial Officer for ReCode Therapeutics, a private company developing genetic medicines; Chief Financial Officer/Chief Business Officer for Rainier Therapeutics, a private company focused on FGFR3 in bladder cancer; Chief Financial Officer/Chief Business Officer for Cascadian Therapeutics, a public company (CASC) focused on Tukysa (tucantinib) in HER2+ breast cancer, through its acquisition by Seagen in 2018. Prior to Cascadian, Ms. Eastland served in a number of financial and strategic roles for VLST Corporation, focused on autoimmune and inflammation biology, Dendreon, an oncology cell therapy company marketing Provenge for prostate cancer, and Amgen.
Ms. Eastland currently serves as a Board member and audit chair at Dynavax Technologies (DVAX), board and audit committee member at Lantheus Holdings Inc (LNTH) and board member at Veana Therapeutics (private). Previously, she was a Board Director and Chair of the Audit Committee for Graybug Vision and Harpoon Therapeutics. She received an M.B.A. from Edinburgh University Management School and a B.S. in finance from Colorado State University.
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ
212-362-1200
emiley.demick@precisionaq.com
WATERTOWN, Mass., August 26, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that company management will participate in the following investor conferences:
Morgan Stanley 22nd Annual Global Healthcare Conference
Date: Thursday, September 5, 2024
Location: New York, NY
Format: Company presentation and 1×1 meetings
Cantor Global Healthcare Conference
Date: Tuesday, September 17, 2024
Location: New York, NY
Format: 1×1 meetings
Stifel 2024 Virtual Immunology and Inflammation Summit
Date: Wednesday, September 18, 2024
Location: Virtual
Format: Company presentation and 1×1 meetings
10th Annual World Medical Innovation Forum
Date: Wednesday, September 25, 2024
Location: Boston, MA
Format: Jo Viney, Ph.D., CEO, will be speaker at the panel presentation titled, “The Disruptors: The Role of Pathway Inhibition in Inflammation and Inflammatory Diseases”
BofA Healthcare Trailblazers Private Company Conference
Date: Wednesday, September 25, 2024
Location: Boston, MA
Format: 1×1 meetings
2024 RBC Capital Markets Biotechnology Private Company Virtual Conference
Date: Tuesday, October 1, 2024
Location: Virtual
Format: Company presentation and 1×1 meetings
Leerink Partners Biopharma Private Company Connect
Date: Wednesday, October 23, 2024
Location: Virtual
Format: 1×1 meetings
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ
212-362-1200
emiley.demick@precisionaq.com
WATERTOWN, Mass., June 25, 2024 — Seismic Therapeutic, Inc., the machine learning immunology company, today announced the appointment of Brendan St. Amant as General Counsel and a member of the company’s leadership team. Mr. St. Amant brings more than 16 years of combined law firm and in-house experience across a range of areas, including corporate governance, securities and disclosure matters, regulatory and corporate compliance, business development and financing transactions, general business law, and managing legal and intellectual property functions at public and private biotechnology companies.
“We are delighted to welcome Brendan to the Seismic leadership team. He joins us at a time when we are rapidly evolving into a clinical-stage company, and his business skills and legal expertise will be highly valuable as we make progress toward important clinical and business milestones,” said Jo Viney, PhD, Co-Founder, President and CEO of Seismic. “Brendan has an outstanding track record as a business leader and legal expert, and his background at biotechnology companies is ideally suited to further strengthen our business excellence and help Seismic capture the tremendous opportunities ahead of us.”
“I am thrilled to join Seismic’s exceptional team and culture at a time when the company has such positive momentum in advancing its pipeline and business,” said Brendan St. Amant. “I look forward to collaborating with the leadership team to help Seismic achieve its goal of creating next generation immunology drugs for patients.”
Prior to joining Seismic, Brendan was General Counsel and Corporate Secretary for Synlogic, Inc., a publicly traded biotech company with a phase 3 clinical drug program. Previously, he was Vice President, Legal, and member of the leadership team at Ohana Biosciences and was senior counsel at Vertex Pharmaceuticals. Brendan was a partner at the law firm of Donnelly, Conroy & Gelhaar, LLP, in Boston where he focused on complex commercial controversies and government enforcement. Earlier in his legal career, Brendan served as a clerk for the Hon. Alvin W. Thompson, Chief, U.S. District Court for the District of Connecticut and was an associate at the law firm of Goodwin Procter. Brendan has served on several practice-related bar committees and on the executive committee of the Board of Trustees of the Massachusetts Continuing Legal Education corporation. He received his BA from Cornell University, JD from Harvard Law School, and his MPP from the Harvard Kennedy School.
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ (formerly known as Stern IR)
212-362-1200
emiley.demick@precisionaq.com
Data to Highlight Machine Learning IMPACT Platform and Emerging Pipeline of Novel Therapeutics to Treat Autoimmune Diseases
Watertown, Mass., June 4, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that the company will participate in three upcoming scientific conferences, presenting data on Seismic’s emerging pipeline of novel therapeutics to treat rare and prevalent autoimmune diseases, as well as its proprietary IMPACT platform that applies machine learning to biologics drug discovery. The company’s two lead drug candidates will be highlighted: S-1117, a novel pan-immunoglobulin (Ig) G protease addressing multiple pathogenic mechanisms in autoimmune disease, and S-4321, a PD-1 agonist:Fc gamma receptor IIb selective Dual-cell Bidirectional (DcB) antibody.
Details of Seismic’s presentations and poster sessions are as follows:
June 11-13 – Structure Based Drug Design Summit, Boston, MA
Presentation Title: Structure Empowered IMPACT Platform in the Discovery & Development of Immunoglobulin Sculpting (IgSc) Enzyme & Dual-Cell Bidirectional (DcB) Antibody Drugs for Immunological Diseases
Session: From Small Molecules to Peptides to Biologics: Dealing with Hard-to-Drug, Dynamic, Proteins with the Structural Biology Toolbox – Case Study Presentations
Date: Thursday, June 13
Time: 1:30 p.m. ET
Presenter: Yi Xing, PhD, Senior Director, Drug Creation
Poster Title: Structural Basis for Fc Domain Selectivity to FcgRIIB
Session: Afternoon Break & Poster Session
Date: Wednesday, June 12
Time: 3:00 p.m. ET
Presenter: Colin Lipper, PhD, Senior Scientist, Drug Creation
June 18-21 – Federation of Clinical Immunology Societies (FOCIS) 2024 Annual Meeting, San Francisco, CA
Poster Title: Identification and Characterization of PD-1 Agonists for the Treatment of Autoimmune and Inflammatory Diseases
Date: Tuesday, June 18
Time: 6:00-7:30 p.m. PT
Poster #: #1735385; Tu131
Presenter: Mike Cianci, M.S. Senior Associate Scientist
Poster Title: Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases
Date: Wednesday, June 19
Time: 1:00-5:00 p.m. PT
Poster #: #1735687; W121
Presenter: Ivan Mascanfroni, PhD, Senior Director, Immunology
June 23-26 – ESACT – European Society for Animal Cell Technology, Edinburgh, Scotland
Presentation Title: Mitigating Risk During Biologics Manufacturing Using Discovery Stage Developability Assays and State of the Art Machine Learning Based Optimization
Session: Session 2 – Transitioning from development to manufacture: How do science and innovation translate into highly efficient biomanufacturing?
Date: Wednesday, June 26
Time: 2:15-3:45 p.m. BST
Presenter: Jyothsna Visweswaraiah, PhD, Director, Drug Creation
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ (formerly known as Stern IR)
212-362-1200
emiley.demick@precisionaq.com
Showcasing major shift in discovery and development of immunology therapies enabled by machine learning
Watertown, Mass., May 29, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that company management will participate in the following June investor conferences:
Jefferies Global Healthcare Conference
Date: Tuesday, June 4, 2024
Location: New York, NY
Format: 1×1 meetings
Leerink Partners Biopharma Private Company Connect
Date: Tuesday, June 25 – Wednesday, June 26, 2024
Location: Virtual
Format: 1×1 meetings
Morgan Stanley 3rd Annual Life Sciences AI Summit
Date: Wednesday June 26 – Thursday, June 27, 2024
Location: New York, NY
Format: Panel and 1×1 meetings
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Precision AQ (formerly known as Stern IR)
212-362-1200
emiley.demick@precisionaq.com
Company’s lead pipeline program in IgG sculpting enzymes demonstrates rapid and sustained reduction of IgG levels and ability to address multiple pathogenic mechanisms
Preclinical findings support S-1117’s differentiated product profile and continued advancement towards clinical development
Watertown, Mass., April 12, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced the presentation of preclinical data for its pan‑immunoglobulin G (IgG) sculpting enzyme candidate, S-1117, at the American Academy of Neurology (AAN) 2024 annual meeting in Denver. The poster presentation titled, “Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases,” features preclinical in vitro and in vivo results supporting the differentiated therapeutic profile of S-1117.
S-1117 is a novel engineered pan-IgG protease targeting IgG autoantibodies that have an important role in the pathogenesis of a range of chronic and acute autoantibody mediated diseases, including the chronic neuromuscular autoimmune disorder, myasthenia gravis.
“Given our pan-IgG sculpting enzyme’s ability to address multiple pathogenic mechanisms as a single drug agent, it has the potential to achieve improved clinical outcomes compared to current therapeutic approaches in chronic autoantibody-mediated diseases,” said Kevin Otipoby, PhD, Chief Research Officer of Seismic Therapeutic. “With the polypharmacology that is possible with S-1117, we aim to overcome existing treatment limitations and achieve higher rates of remission for patients with chronic autoantibody mediated diseases. We are excited to continue to advance S-1117 towards first-in-human clinical studies.”
The preclinical data presented at AAN describe results across a variety of measures that support the differentiated profile of S-1117 compared to therapeutic benchmarks in chronic autoantibody-mediated diseases. S-1117 addresses multiple mechanisms of autoimmunity, as shown by the preclinical results that demonstrated rapid and deep lowering of IgG and immune complex levels, reducing IgG effector functions, and cleaving the antigen B‑cell receptor (BCR) on memory B cells.
In vitro studies demonstrated S-1117’s ability to cleave soluble and membrane-bound forms of IgG, including the BCR, and to reduce tissue-damaging IgG effector functions:
In vivo studies performed in mouse models with S-1117 or Fc-fused pan-IgG protease progenitor molecule demonstrated the compound’s ability to lower pathogenic IgG and immune complex levels:
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Stern Investor Relations
212-362-1200
emiley.demick@sternir.com
Growing body of scientific evidence demonstrates productivity of IMPACT platform and rapidly expanding pipeline opportunity in immunology
Watertown, Mass., April 9, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that the company will participate in four upcoming scientific conferences, presenting the company’s emerging pipeline of novel therapeutics to treat rare and prevalent autoimmune diseases, as well as its proprietary IMPACT platform that applies machine learning to biologics drug discovery.
“The bolus of preclinical data we are presenting in the coming months highlights the immense potential of Seismic’s pipeline in autoimmune diseases,” said Jo Viney, PhD, Founder, President and CEO of Seismic Therapeutic. “In just two years since the company’s founding, we have internally developed two potentially best-in-class development candidates as well as a number of discovery-stage programs, and these presentations from Seismic’s expert team of scientists underscore the productivity of our IMPACT platform in drug discovery. We look forward to progressing S-1117 and S-4321 through IND-enabling studies, as we work to deliver the next-generation of novel biologics to patients suffering from a variety of autoimmune diseases.”
Details of Seismic’s presentations and poster sessions are as follows:
April 16-18 – 4th Fc-Mediated Function Summit
Presentation Title: Fine-Tuning Antibody-Based Immunotherapy Identification & Characterization of FcγRIIb Selective PD-1 Agonist Antibodies to Treat Autoimmunity & Inflammation
Date: Wednesday, April 17
Time: 3:00 p.m. ET
Section: Targeting FcyR in its Own Right – What is the Next Mutation?
Presenter: Daniela Cipolletta, PhD, Senior Director of Immunology, Seismic Therapeutic
May 3-7 – IMMUNOLOGY2024™, Annual Meeting of the American Association of Immunologists
Poster Title: Identification and Characterization of PD-1 Agonists for the Treatment of Autoimmune and Inflammatory Diseases
Date: Monday, May 6
Time: 7:00 a.m. CT
Poster #: B887
Presenter: Maria Cecilia Ramello, PhD, Senior Scientist, Seismic Therapeutic
Poster Title: Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases
Date: Saturday, May 4
Time: 7:00 a.m. CT
Poster #: B859
Presenter: Ivan Mascanfroni, PhD, Senior Director of Immunology, Seismic Therapeutic
In addition to the poster presentations, Seismic management will participate in the following sessions at IMMUNOLOGY2024:
Session Title: Recent Breakthroughs and Emerging Therapeutic Strategies for Chronic Inflammatory and Fibrotic Disease
Session Presentation Title: The polypharmacology of dual cell bidirectional (DcB) agonist antibodies for treating autoimmunity
Date: Saturday, May 4
Time: 8:00 a.m. CT
Session Co-Chair & Presenter: Jo Viney, PhD, Founder, CEO and President, Seismic Therapeutic
Session Title: Therapeutic Intervention for Treating Immune Dysregulation in Inflammation and Cancer
Date: Sunday, May 5
Time: 4:30 p.m. CT
Co-Moderator: Ivan Mascanfroni, PhD, Senior Director of Immunology, Seismic Therapeutic
May 13-17 – 20th Annual PEGS Boston Summit
Presentation Title: Dual Cell Bidirectional Antibodies for Treating Autoimmunity
Session: Variety of mechanisms using bispecific antibodies
Date: Wednesday, May 15
Time: 3:00 p.m. ET
Presenter: Jyothsna Visweswaraiah, PhD, Director of Drug Creation, Seismic Therapeutic
Poster Title: Characterization of PD1 Agonizing Dual cell Bidirectional Antibodies to Treat Autoimmune Diseases
Presenter: Rasika Harshe, M.S., Senior Associate Scientist II, Seismic Therapeutic
Poster Title: Discovery and Characterization of FcγRIIb Selective Antibodies to Enhance Checkpoint Agonism and Treat Autoimmunity
Presenter: Ishan Sharma, M.S., Scientist, Seismic Therapeutic
Poster Title: Accelerating The Discovery Of A Pan-Igg Protease Using The IMPACT Platform
Presenter: Soumya Bengeri, M.S., Senior Associate Scientist, Seismic Therapeutic
Poster Title: Design and Screening of FcγRIIb Selective Fc Domains to Enhance Checkpoint Agonism and Treat Autoimmunity
Presenter: Samuel Perry, PhD, Senior Scientist, Seismic Therapeutic
May 21-23 – 6th Treg Directed Therapies Summit
Presentation Title: Integration of Treg Biology and Immunotherapy
Session Category: Exploring the Impact of Treg Biology on Development of Treg Directed Therapies to Drive Precise Therapeutic Interventions.
Date: Tuesday, May 21
Time: 12:00 p.m. ET
Presenter: Marisella Panduro, PhD, Principal Scientist, Seismic Therapeutic
Presentation Title: Inhibitory Receptor Targeting & Modulation of Treg Biology
Session Category: Non-Cell Based Approaches
Date: Thursday, May 23
Time: 11:30 a.m. ET
Presenter: Daniela Cipolletta, PhD, Senior Director of Immunology, Seismic Therapeutic
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
Investor Contact
Emiley Demick, Stern Investor Relations
212-362-1200
emiley.demick@sternir.com
Watertown, Mass., March 8, 2024 – Seismic Therapeutic, Inc., the machine learning immunology company, today announced that the company will present preclinical data for its pan-immunoglobulin G (IgG) sculpting enzyme candidate, S-1117, at the American Academy of Neurology (AAN) annual meeting taking place on April 13-18 in Denver.
S-1117 is a novel engineered pan-IgG protease for the potential treatment of a range of chronic and acute autoantibody mediated diseases, including the chronic neuromuscular autoimmune disorder, myasthenia gravis. The presentation at the AAN annual meeting will outline key preclinical in vitro and in vivo results supporting the differentiated profile of S-1117 compared to therapeutic benchmarks in chronic autoantibody mediated diseases. S-1117 addresses multiple mechanisms of autoimmunity by lowering IgG and immune complex levels, reducing IgG effector functions and cleaving the antigen receptor (BCR) on memory B cells. Moreover, in a mouse pharmacokinetic model, S-1117 was able to achieve deep, sustained and rapid reduction in human IgG.
Presentation details:
Title: Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases
Session: P4 – Autoimmune Neurology: Peripheral Autoimmunity
Date: Monday, April 15, 2024
Time: 11:45 a.m. – 12:45 p.m. MT
Area: 14
Poster number: 018
Abstract number: 6869
About Seismic Therapeutic
Seismic Therapeutic™ is a biotechnology company making a major shift in how immunology therapies are discovered and developed, enabled by machine learning. The company has a growing preclinical stage best-in-class and first-in-class biologics pipeline, derived from its integrated IMPACT platform, to control dysregulated adaptive immunity and address multiple autoimmune diseases. The company is backed by a strong syndicate of life sciences investors and is located in the Boston biotechnology hub. For more information, please visit www.seismictx.com and follow us on LinkedIn and on X @Seismic_Tx.
Media Contact
Kathryn Morris, The Yates Network
914-204-6412
kathryn@theyatesnetwork.com
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