At Seismic, our open and hyper-collaborative process is what yields results. We gain focus alongside curiosity. We are dedicated to our rigorous science and determined to have impact for patients. Doing it all, together, is what keeps us going. Let’s fuse our ideas and open the door to the uncharted.

While we are focused on this new era of drug discovery, our main focus is our why: creating IMPACT for patients.

We need you on our team.

Get Inspired at Seismic.

Director of Finance, FP&A

About Seismic Therapeutic:

Seismic is determined to help patients with unmet need by integrating machine learning, structural biology, protein engineering, and translational immunology to generate clinic-ready medicines. At our core, we are focused on phenomenal science, supportive culture, a diverse team, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will be the discovery and development of effective therapies for patients in need, and we invite you to become a part of that.

Our office and lab are in Watertown, MA.

About The Role:

Seismic Therapeutic, a biotechnology startup focused on the intersection of structure, protein engineering, machine learning and immunology, is seeking a Director of Finance to build our FP&A capabilities and assist in the monthly close and reporting process. This position reports to the Vice President of Finance.

Responsibilities:

  • Lead the vendor accrual process for the monthly close partnering with the business and external vendors to record expenses in compliance with GAAP
  • Responsible for internal financial reporting, including monthly comparison of actual vs. budget results
  • Collaborate with the Accounting team on the monthly close to ensure the books are closed accurately and promptly
  • Lead the development of annual budgets, long range planning, and periodic forecast updates
  • Develop financial models and ad-hoc analyses to support strategic initiatives and decision-making.
  • Assist in the preparation of presentations to the Board of Directors and Senior Management Team
  • Serve as a strategic business partner to functional groups
  • Assist with the oversight of the procurement and purchasing processes and ensure proper coding of expenses

Who You Are:

  • Strong ability to build good working relationships with cross-functional business teams. Work effectively in and contribute to a team environment. Approaches work with a positive, team-first attitude.
  • Outstanding written and verbal communication skills, including running meetings and preparing presentations for internal and external groups. Ability to communicate effectively with the team and Senior Management.
  • Someone who will embrace Seismic’s culture, values and exhibits a high degree of integrity and ethics, and shares Seismic’s commitment to an inclusive and supportive culture.

Qualifications:

  • Bachelor’s in Finance, Accounting or a relevant degree
  • 8+ years of relevant work experience
  • Prior experience working in the pharmaceutical or biotechnology industry
  • Strong knowledge of GAAP, SEC reporting, and experience with public company compliance.
  • Highly skilled in Excel and PowerPoint
  • Strong written, verbal, and interpersonal skills
  • Experience with FP&A planning tools and ERPs (QuickBooks and NetSuite)

This position will be based in our Watertown, MA office location. We are not currently considering remote applicants.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion and talent – we’ll bring novel therapeutics to the patients who need them the most.

APPLY HERE

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

Senior Scientist, Preclinical Translation

Seismic is determined to help patients with unmet need by integrating machine learning, structural biology, protein engineering, and translational immunology to generate clinic-ready medicines. At our core, we are focused on phenomenal science, supportive culture, a diverse team, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. We have an exciting opportunity for an experienced and motivated Senior Scientist to help drive novel immunotherapy programs. The candidate must be independent, goal oriented, flexible, and able to work efficiently across multiple projects. We are searching for enthusiastic, and innovative individuals with a deep scientific background in drug metabolism and pharmacokinetics (DMPK) who thrive in a fast-paced, entrepreneurial environment.

Responsibilities:

  • Work closely with project team leads to help design PK/PD studies and lead DMPK efforts to optimize molecules utilizing in vitro, in vivo, and in silico methods and models.
  • Provide scientific leadership in the discovery of large molecule drug candidates by integrating DMPK strategy to progress drug discovery project.
  • Work closely with CROs and external stakeholders for all DMPK related activities
  • Help plan and analyze  in vitro & in vivo experiments, as well as effectively communicate results to peers and senior leadership
  • Make independent decisions related to day-to-day experimental activities

Basic Requirements

  • Ph.D. with 5+ years, MSc with 12+ years or BSc with 15+ years of relevant experience
  • Excellent understanding of ADME principals with knowledge of PK/PD modeling of large molecules
  • Previous experience working with antibodies and Fc fusion proteins
  • Knowledge of of bioassay development principles and data interpretation is preferred
  • Understanding of immunology, immunotherapy and autoimmunity is preferred
  • Demonstrated ability to organize and clearly communicate complex data sets to peers and senior leadership
  • Scientifically rigorous but comfortable taking calculated risks with imperfect knowledge
  • Ability to work within a team, excellent verbal and written communication and interpersonal skills
  • Self-motivated, conscientious, and passionate about improving patients’ lives

What we offer you: As a member of our growing team, you will help us achieve the Preclinical Translation team’s impact and contributions. We not only take our scientific mission seriously but also provide a positive and supportive workplace environment and culture. Seismic will have the opportunity to benefit from the insight, diversity, and talent that you’ll bring. Together, we’ll help bring therapeutics to the patients who need them most.

Our mission: Seismic is determined to help patients in need, starting with novel approaches to protein engineering, machine learning and immunology, and ending with clinic-ready drugs. At our core, our focus is on phenomenal science, meritocracy, a superstar team, supportive culture, and patient-centric goals. Seismic has the tools, skills, ideas and people to make this a reality. Success will enable treatment for millions of patients with currently incurable, often disabling and deadly diseases, and we invite you to become a part of that.

APPLY HERE

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

Scientist / Senior Scientist, Machine Learning

About Seismic

Seismic Therapeutic, a cutting-edge biomedicines company at the intersection of machine learning, protein engineering, and immunology, is seeking a creative, independently-minded machine learning scientist to help accelerate the Impact Platform for the computational discovery and optimization of new biologic drugs. Seismic’s machine learning platform enables on-demand generation and optimization of protein therapeutics to fight diseases of the immune system, using the power of artificial intelligence to translate audacious ideas into breakthrough drugs. We are dedicated to building a supportive culture around a superstar team, while keeping the unmet needs of patients at the center of our goals. Seismic has the tools, skills, ideas and people to make this vision a reality.

Working closely with our team of machine learning scientists, structural biologists, immunologists and others, you will develop and apply innovative machine learning approaches to optimize natural proteins for clinical applications and design novel classes of synthetic proteins with therapeutic functions.

Who you are and what you bring:

  • A rigorous machine learning scientist with a deep understanding of molecular biology, protein biochemistry and structure.
  • Appreciation of the characteristics that make a robust biologic drug.
  • Hands-on experience with protein design models incorporating sequence (evolutionary sequence models and large language models) and/or structure (diffusion and inverse folding models).
  • Ability to communicate complex machine learning and computational concepts to audiences with a wide range of backgrounds and technical familiarity.
  • Experience working with wet lab teams to bridge the divide from in-silico designs to real-world applications.
  • Driven and conscientious, thriving in a fast-paced, entrepreneurial environment.
  • Passionate about improving patients’ lives.

Core Responsibilities:

  • Design and train new classes of machine learning models to optimize natural proteins for therapeutic properties and design synthetic proteins with novel therapeutic functions.
  • Spearhead computational de novo antibody design efforts to create new therapeutics targeting challenging antigens.
  • Integrate diverse external and internal data sources including protein sequence, structure, function, and molecular characterization data to enable detailed modulation and multi-objective optimization of protein properties.
  • Work with a diverse team of protein scientists, immunologists, and clinical experts to tailor modeling efforts toward high-impact therapeutic applications.
  • Establish robust data infrastructure to enable machine learning model training and deployment of data analysis and visualization tools.
  • Develop production-quality code in a team setting for use by both computational and wet-lab scientists.
  • Present progress from scientific work in regular meetings and prepare reports and slide decks for broader internal and external communication.

Required Qualifications:

  • PhD in Mathematics, Computational Biology, Computer Science, Statistics or a related field. Exceptional candidates with extensive computational experience and a PhD in a non-computational field will also be considered.
  • 3+ years of industry experience with developing and applying machine learning methods to create new biological drugs, using deep learning models such as variational autoencoders and graph neural networks.
  • Application of ML in the field of drug discovery is essential with hands-on experience in the following: protein engineering, or statistical genetics are especially relevant.
  • Demonstrated experience collaborating with wet lab scientists to generate and analyze real-world data in an applied setting, especially in the context of pharmaceutical development.
  • Proficiency in Python and data analysis with Numpy/Scipy, R, or another statistical programming language.
  • A strong drive to collaborate and communicate with a diverse and vibrant team of both dry and wet lab scientists.

It’s a plus but not required:

  • Experience with AWS, Google Cloud, or another cloud computing framework.
  • Familiarity with Dash, R Shiny, or another interactive app development framework.
  • Application of ML in the fields of genomics and immunology.
  • Publications in major scientific journals that apply machine learning methods to problems in molecular or structural biology.

As a member of our diverse and growing team, you’ll help shape Seismic into a company that takes its scientific mission seriously while providing a positive and supportive workplace environment and culture. With your insights, passion, and talent – we’ll bring novel therapeutics to the patients who need them the most.

APPLY HERE

Seismic Therapeutic is an equal opportunity employer. We will not tolerate discrimination on the basis of race, color, national origin, sex, sexual orientation, gender identity, religion, age, disability, veteran’s status, pregnancy, genetic information or on any basis prohibited by federal, state or local law.

Alert about deceptive recruitment activities:
Please be aware of the potential for scams from individuals, organizations and internet sites that claim to represent Seismic Therapeutic in recruitment activities. They may be trying to fraudulently collect sensitive personal information and, if so, please report any suspicious activity to local authorities for identity theft. Seismic conducts a formal recruitment process for all authorized positions. Unless you apply directly to a job listing, we will not contact you via text message, email or any other channels.

Inspired
to do more.
Being a Seismonaut means being relentlessly curious, open, transparent, and decisive. But above all, putting the team first. Here’s how we do it:
Intensive
At Our Core
We have our eyes on the prize - combining a level of accountability with exceptional, exciting science, but we also have a serious respect for our goals and believe in our people.
Inclusive
In Our Approach
We are open to the possibilities of the new and the uncharted. We fully believe that our impact on the drug discovery paradigm directly correlates to our willingness to embrace curiosity.
Integrative
In Our Process
We believe our hyper-collaborative style provides a fertile ground for discovery, having a positive impact both inside and outside of Seismic.

A Space for Seismic Discovery

Shifting the horizon requires creating the right environment for our Seismonauts to thrive. Our space fosters the inclusivity and integration we run on – with open collaborative work areas that allow cross- pollination of interests and departments. However, setting the stage for success goes beyond our galaxy walls. Seismic offers a competitive benefits package that is structured to create balance and maintain the expertise and talent we need on our mission.

Be an IMPACTor

Our team of Seismonauts is passionate about shifting things for the better, not only in developing breakthrough medicines, but also in making a difference to the causes and communities that matter to us.

Our IMPACTor Leaders show us the way. As an employee-led collaborative, IMPACTors initiate social events, elevate diversity awareness, and host philanthropic and volunteer activities. These initiatives are proudly started within Seismic, but have profound impact in the community.

© 2024 SEISMIC TX. ALL RIGHTS RESERVED.
 
 

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